At the start of the twentieth century, Dr. John W. Thackery takes over as the chief surgeon at the Knickerbocker Hospital in New York and deals with a racially charged city and drug addiction.

Method and Madness
Dr Thackery is Chief Of Medicine in a 1900 New York hospital, The Kickerbocker, battling a cocaine addiction, high mortality rates and bureaucratic corruption to save lives in a world before antibiotics and blood transfusions.

Mr. Paris Shoes
Already fuming over the hospital's faulty new electrical system, Thackery tasks Herman Barrow, The Knick's crooked superintendent, to deliver more cadavers so he and his team can test out ...

The Busy Flea
An old friend of Thackery's, Abbie Alford, arrives at the hospital seeking his help. She has lost most of her nose as the result of syphilis, which she acquired from her now absent husband....

Where's the Dignity
Dr. Edwards is finally invited into the surgical theater but Thackery makes it clear that he's only there to guide Dr. Gallinger through the procedure. Herman Barrow is making money any way...

They Capture the Heat
Gangster Bunky Collier shows up at the Knick after one of his pimps is shot in the leg. Thackery is called in to perform the surgery and is surprised to find Edwards there at that early ...

Start Calling Me Dad
Having lost yet another patient while performing a Cesarean section, Thackery develops a completely new method to reduce the bleeding and invites Bertie Chickering to help him experiment. ...

Get the Rope
A riot breaks out when a police officer is stabbed by a black man defending his wife. The employees of the Knickerbocker fight to protect the lives of blacks injured in the riots.

Working Late a Lot
Thackery's affair with Nurse Lucy Elkins continues. Bertie continues to pursue her. There is a shortage of cocaine due to the war in the Philippines and attacks on shipping. It has a ...

The Golden Lotus
The Knick continues its slide into wrack and ruin, instigated by the recent riot and the cocaine shortage. Dr. Thackery is caught in a compromising position and Lucy in her efforts to help ...

Crutchfield
Thackery's drug habit is catching up with him. He is growing increasingly paranoid as he is unable to perform even when under the drug's influence. When he learns that Dr. Levi Zinberg is ...
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